| ncRNA name | hsa-miR-15a |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human blood; human retinal Müller glial cell line MIO-M1; human retinal endothelial cells (HRECs); human RPE cells (HRPEs) |
| Methods | microarray, qRT-PCR, transfection, Western blot, apoptosis staining, immunohistochemical staining |
| Expression pattern | up-regulated |
| Functional description | miR-15a is increased in the plasma of diabetic patients, correlating with disease severity.We postulate that miR-15a, produced in pancreatic β-cells, can enter the bloodstream and contribute to retinal injury. miR-15a overexpression in Müller cells can be induced by exposing Müller cells to exosomes derived from INS-1 cells under high-glucose conditions and results in oxidative stress by targeting Akt3, which leads to apoptotic cell death. |
| PubMed ID | 28173719 |
| Year | 2017 |
| Title | Exosomal MicroRNA-15a Transfer from the Pancreas Augments Diabetic Complications by Inducing Oxidative Stress. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.